| http://purl.uniprot.org/citations/24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24713432 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Jun N-terminal protein kinase (JNK) and its two direct activators, namely the mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) and MKK7, constitute a signaling node frequently mutated in human pancreatic ductal adenocarcinoma (PDAC). Here we demonstrate the cooperative interaction of endogenous expression of Kras(G12D) with loss-of-function mutations in mkk4 or both, mkk4 and mkk7 genes in the pancreas. More specifically, impaired JNK signaling in a subpopulation of Pdx1-expressing cells dramatically accelerated the appearance of Kras(G12D)-induced acinar-to-ductal metaplasia and pancreatic intraepithelial neoplasias, which rapidly progressed to invasive PDAC within 10 weeks of age. Furthermore, inactivation of mkk4/mkk7 compromised acinar regeneration following acute inflammatory stress by locking damaged exocrine cells in a permanently de-differentiated state. Therefore, we propose that JNK signaling exerts its tumor suppressive function in the pancreas by antagonizing the metaplastic conversion of acinar cells toward a ductal fate capable of responding to oncogenic stimulation."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-13-2941"xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "Tuveson D.A."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "Davis R.J."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "Connor F."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "Harvey E."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "Tournier C."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "Davies C.C."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "McMahon R.F."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/author | "Finegan K.G."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/pages | "3344-3356"xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/title | "Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/24713432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24713432 |
| http://purl.uniprot.org/citations/24713432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24713432 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY1-mappedCitation-24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24713432 |
| http://purl.uniprot.org/uniprot/#_Q0VDV7-mappedCitation-24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24713432 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQK8-mappedCitation-24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24713432 |
| http://purl.uniprot.org/uniprot/#_B1ATL6-mappedCitation-24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24713432 |
| http://purl.uniprot.org/uniprot/#_B2KGV5-mappedCitation-24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24713432 |
| http://purl.uniprot.org/uniprot/#_E9Q8V2-mappedCitation-24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24713432 |
| http://purl.uniprot.org/uniprot/#_M0QW52-mappedCitation-24713432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24713432 |