| http://purl.uniprot.org/citations/24717539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24717539 | http://www.w3.org/2000/01/rdf-schema#comment | "While T-cell responses are directly modulated by Toll-like receptor (TLR) ligands, the mechanism and physiological function of nucleic acids (NAs)-mediated T cell costimulation remains unclear. Here we show that unlike in innate cells, T-cell costimulation is induced even by non-CpG DNA and by self-DNA, which is released from dead cells and complexes with antimicrobial peptides or histones. Such NA complexes are internalized by T cells and induce costimulatory responses independently of known NA sensors, including TLRs, RIG-I-like receptors (RLRs), inflammasomes and STING-dependent cytosolic DNA sensors. Such NA-mediated costimulation crucially induces Th2 differentiation by suppressing T-bet expression, followed by the induction of GATA-3 and Th2 cytokines. These findings unveil the function of NA sensing by T cells to trigger and amplify allergic inflammation."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms4566"xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Hirano H."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Kimura Y."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Imanishi T."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Taniguchi S."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Noda T."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Barber G.N."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Brombacher F."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Ishihara C."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Hashimoto-Tane A."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/author | "Badr M.e.l. S."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/pages | "3566"xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/title | "Nucleic acid sensing by T cells initiates Th2 cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24717539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24717539 |
| http://purl.uniprot.org/citations/24717539 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24717539 |