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Background and aims

Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1).

Methods

Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured.

Results

After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores.

Conclusions

Our results show that ATOR protects the liver from I/R injury."xsd:string
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http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/author"Alarcon-Galvan G."xsd:string
http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/author"Camara-Lemarroy C.R."xsd:string
http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/author"Cordero-Perez P."xsd:string
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http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/name"Arch Med Res"xsd:string
http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/pages"210-216"xsd:string
http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/title"Hepatic ischemia/reperfusion injury is diminished by atorvastatin in Wistar rats."xsd:string
http://purl.uniprot.org/citations/24726586http://purl.uniprot.org/core/volume"45"xsd:string
http://purl.uniprot.org/citations/24726586http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24726586
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