| http://purl.uniprot.org/citations/24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24733584 | http://www.w3.org/2000/01/rdf-schema#comment | "Most chemical neurotransmission occurs through Ca(2+)-dependent evoked or spontaneous vesicle exocytosis. In both cases, Ca(2+) sensing is thought to occur shortly before exocytosis. In this paper, we provide evidence that the Ca(2+) dependence of spontaneous vesicle release may partly result from an earlier requirement of Ca(2+) for the assembly of soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes. We show that the neuronal vacuolar-type H(+)-adenosine triphosphatase V0 subunit a1 (V100) can regulate the formation of SNARE complexes in a Ca(2+)-Calmodulin (CaM)-dependent manner. Ca(2+)-CaM regulation of V100 is not required for vesicle acidification. Specific disruption of the Ca(2+)-dependent regulation of V100 by CaM led to a >90% loss of spontaneous release but only had a mild effect on evoked release at Drosophila melanogaster embryo neuromuscular junctions. Our data suggest that Ca(2+)-CaM regulation of V100 may control SNARE complex assembly for a subset of synaptic vesicles that sustain spontaneous release."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201312109"xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Quiocho F.A."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Srinivasan S."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Epstein D."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Hiesinger P.R."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Williamson W.R."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Khalaf O."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/author | "Fayyazuddin A."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/pages | "21-31"xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/title | "Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1."xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://purl.uniprot.org/core/volume | "205"xsd:string |
| http://purl.uniprot.org/citations/24733584 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24733584 |
| http://purl.uniprot.org/citations/24733584 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24733584 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF57-mappedCitation-24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24733584 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCZ4-mappedCitation-24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24733584 |
| http://purl.uniprot.org/uniprot/#_A0A126GV04-mappedCitation-24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24733584 |
| http://purl.uniprot.org/uniprot/#_Q24547-mappedCitation-24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24733584 |
| http://purl.uniprot.org/uniprot/#_P36975-mappedCitation-24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24733584 |
| http://purl.uniprot.org/uniprot/#_P62152-mappedCitation-24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24733584 |
| http://purl.uniprot.org/uniprot/#_Q6NLA3-mappedCitation-24733584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24733584 |