| http://purl.uniprot.org/citations/24733933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24733933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24733933 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila Toll receptors are involved in embryonic development and the immune response of adult flies. In both processes, the only known Toll receptor ligand is the human nerve growth factor-like cystine knot protein Spätzle. Here we present the crystal structure of a 1:1 (nonsignaling) complex of the full-length Toll receptor ectodomain (ECD) with the Spätzle cystine knot domain dimer. The ECD is divided into two leucine-rich repeat (LRR) domains, each of which is capped by cysteine-rich domains. Spätzle binds to the concave surface of the membrane-distal LRR domain, in contrast to the flanking ligand interactions observed for mammalian Toll-like receptors, with asymmetric contributions from each Spätzle protomer. The structure allows rationalization of existing genetic and biochemical data and provides a framework for targeting the immune systems of insects of economic importance, as well as a variety of invertebrate disease vectors."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1320678111"xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1320678111"xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Lilie H."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Lilie H."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Breithaupt C."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Breithaupt C."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Fandrich U."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Fandrich U."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Parthier C."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Parthier C."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Stelter M."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Stelter M."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Stubbs M.T."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Stubbs M.T."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Ursel C."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/author | "Ursel C."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/pages | "6281-6286"xsd:string |
| http://purl.uniprot.org/citations/24733933 | http://purl.uniprot.org/core/pages | "6281-6286"xsd:string |