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http://purl.uniprot.org/citations/24736082http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24736082http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Anaplastic lymphoma kinase (ALK) fusion is the most common mechanism for overexpression and activation in non-small-cell lung carcinoma. Several fusion partners of ALK have been reported, including echinoderm microtubule-associated protein-like 4, TRK-fused gene, kinesin family member 5B, kinesin light chain 1 (KLC1), protein tyrosine phosphatase and nonreceptor type 3, and huntingtin interacting protein 1 (HIP1).

Methods and results

A 60-year-old Korean man had a lung mass which was a poorly differentiated adenocarcinoma with ALK overexpression. By using an Anchored Multiplex polymerase chain reaction assay and sequencing, we found that tumor had a novel translocated promoter region (TPR)-ALK fusion. The fusion transcript was generated from an intact, in-frame fusion of TPR exon 15 and ALK exon 20 (t(1;2)(q31.1;p23)). The TPR-ALK fusion encodes a predicted protein of 1192 amino acids with a coiled-coil domain encoded by the 5'-2 of the TPR and juxtamembrane and kinase domains encoded by the 3'-end of the ALK.

Conclusions

The novel fusion gene and its protein TRP-ALK, harboring coiled-coil and kinase domains, could possess transforming potential and responses to treatment with ALK inhibitors. This case is the first report of TPR-ALK fusion transcript in clinical tumor samples and could provide a novel diagnostic and therapeutic candidate target for patients with cancer, including non-small-cell lung carcinoma."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.org/dc/terms/identifier"doi:10.1097/jto.0000000000000093"xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Han J."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Kim J."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Song J.Y."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Zheng Z."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Mao M."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Hong M."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Choi S.J."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Choi Y.L."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Lira M.E."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Mann D.L."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Kim R.N."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Stahl J.A."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Peckham H.E."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/author"Pandy K."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/name"J Thorac Oncol"xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/pages"563-566"xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/title"A novel fusion of TPR and ALK in lung adenocarcinoma."xsd:string
http://purl.uniprot.org/citations/24736082http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/24736082http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24736082
http://purl.uniprot.org/citations/24736082http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24736082
http://purl.uniprot.org/uniprot/#_A0A0K2YUJ3-mappedCitation-24736082http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24736082
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