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http://purl.uniprot.org/citations/24737799http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24737799http://www.w3.org/2000/01/rdf-schema#comment"

Background

Natural killer (NK) cells provide a major defense against cytomegalovirus (CMV) infection through the interaction of their surface receptors, including the activating and inhibitory killer immunoglobulin-like receptors (KIRs), and human leukocyte antigens (HLA) class I molecules. This study assessed whether the KIR and HLA repertoire may influence the risk of developing symptomatic or asymptomatic disease after primary CMV infection in the immunocompetent host.

Methods

Sixty immunocompetent patients with primary symptomatic CMV infection were genotyped for KIR and their HLA ligands, along with 60 subjects with a previous asymptomatic infection as controls.

Results

The frequency of the homozygous A haplotype (only KIR2DS4 as activating KIR) was higher in symptomatic patients than controls (30% vs 12%, respectively; odds ratio [OR] = 3.24; P = .01). By logistic regression, the risk of developing symptomatic disease was associated with the homozygous A haplotype and the HLABw4(T) allele. Combining the 2 independent variables, we found that 37 out of 60 (62%) symptomatic patients but only 18 out of 60 (30%) of controls possessed the homozygous A haplotype or the HLABw4(T) allele with a highly significant OR (OR = 3.75, P < .0005).

Conclusions

Immunocompetent subjects carrying the homozygous A haplotype or the HLABw4(T) allele are at higher risk of developing symptomatic disease after primary CMV infection."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.org/dc/terms/identifier"doi:10.1093/infdis/jiu226"xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Caruso C."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Duro G."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Montalto G."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Giammanco G."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Colomba C."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"De Grazia S."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Cippitelli M."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Di Bona D."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Nuzzo D."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Plaia A."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Scafidi V."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Tuttolomondo A."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/author"Occhino C."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/name"J Infect Dis"xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/pages"1083-1089"xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/title"HLA and killer cell immunoglobulin-like receptors influence the natural course of CMV infection."xsd:string
http://purl.uniprot.org/citations/24737799http://purl.uniprot.org/core/volume"210"xsd:string
http://purl.uniprot.org/citations/24737799http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24737799
http://purl.uniprot.org/citations/24737799http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24737799
http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-24737799http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24737799
http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-24737799http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24737799
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