| http://purl.uniprot.org/citations/24738946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24738946 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer cells possess fundamentally altered metabolism that supports their pathogenic features, which includes a heightened reliance on aerobic glycolysis to provide precursors for synthesis of biomass. We show here that inositol polyphosphate phosphatase 1 (INPP1) is highly expressed in aggressive human cancer cells and primary high-grade human tumors. Inactivation of INPP1 leads to a reduction in glycolytic intermediates that feed into the synthesis of the oncogenic signaling lipid lysophosphatidic acid (LPA), which in turn impairs LPA signaling and further attenuates glycolytic metabolism in a feed-forward mechanism to impair cancer cell motility, invasiveness, and tumorigenicity. Taken together these findings reveal a novel mode of glycolytic control in cancer cells that can serve to promote key oncogenic lipid signaling pathways that drive cancer pathogenicity."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.org/dc/terms/identifier | "doi:10.1021/cb5001907"xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Kohnz R.A."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Chan L.G."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Nomura D.K."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Bandyopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Goga A."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Li D.S."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Ng S.W."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Sorrentino A."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Louie S.M."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Mulvihill M.M."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Benjamin D.I."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Cozzo A."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/author | "Ohiri A."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/name | "ACS Chem Biol"xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/pages | "1340-1350"xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/title | "Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness."xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24738946 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24738946 |
| http://purl.uniprot.org/citations/24738946 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24738946 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3X1-mappedCitation-24738946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24738946 |
| http://purl.uniprot.org/uniprot/#_B3KSH8-mappedCitation-24738946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24738946 |