| http://purl.uniprot.org/citations/24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24740410 | http://www.w3.org/2000/01/rdf-schema#comment | "Alveolar type I epithelial cells (AECIs) play an important role in the pathogenesis of acute lung injury. The receptor for advanced glycation end-products (RAGEs) is expressed at a high basal level in AECIs, and its soluble isoform is suggested as a marker of AECI injury. However, the molecular mechanism by which RAGE mediates inflammatory injury in AECIs remains elusive. In this study, we established lipopolysaccharide (LPS)-induced inflammation in AECIs isolated from neonate rats as the experimental model and investigated the role of RAGE/NF-κB signaling in mediating inflammatory response in AECIs. We found that LPS increased RAGE expression and the secretion of tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) in AECIs in a dose-dependent manner. Knockdown of RAGE significantly decreased TNF-α and IL-1β levels in conditioned medium of AECIs. Electrophoretic mobility shift assay (EMSA) showed that NF-κB activation was increased in AECIs treated by LPS. However, knockdown of RAGE inhibited both basic and LPS-induced NF-κB activity in AECIs. Finally, NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced LPS-induced upregulation of RAGE expression at both protein and messenger RNA (mRNA) levels in AECIs. Our results suggest that RAGE mediates inflammatory response in AECIs via activating NF-κB, and RAGE/NF-κB pathway presents potential target for the prevention and therapy of acute lung injury."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10753-014-9889-y"xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/author | "Cheng H."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/author | "Tian Z."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/author | "Wu R."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/author | "Ji P."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/name | "Inflammation"xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/pages | "1623-1629"xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/title | "RAGE/NF-kappaB pathway mediates lipopolysaccharide-induced inflammation in alveolar type I epithelial cells isolated from neonate rats."xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/24740410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24740410 |
| http://purl.uniprot.org/citations/24740410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24740410 |
| http://purl.uniprot.org/uniprot/#_A6KTG2-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |
| http://purl.uniprot.org/uniprot/#_A6KTG3-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |
| http://purl.uniprot.org/uniprot/#_A6KTG4-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |
| http://purl.uniprot.org/uniprot/#_A6HVY5-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |
| http://purl.uniprot.org/uniprot/#_A6HVY6-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |
| http://purl.uniprot.org/uniprot/#_A6HVY7-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |
| http://purl.uniprot.org/uniprot/#_F1ABR3-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |
| http://purl.uniprot.org/uniprot/#_F1ABR4-mappedCitation-24740410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24740410 |