| http://purl.uniprot.org/citations/24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24742225 | http://www.w3.org/2000/01/rdf-schema#comment | "CEB1 is a highly polymorphic human minisatellite. In yeast, the size variation of CEB1 tandem arrays has been associated with the capacity of the motif to form G-quadruplexes. Here we report on the NMR solution structure of a G-quadruplex formed by the CEB1 DNA G-rich fragment d(AGGGGGGAGGGAGGGTGG), harboring several G-tracts including one with six continuous guanines. This sequence forms a dimeric G-quadruplex involving the stacking of two subunits, each being a unique snapback parallel-stranded scaffold with three G-tetrad layers, three double-chain-reversal loops, and a V-shaped loop. The two subunits are stacked at their 5'-end tetrads, and multiple stacking rotamers may be present due to a high symmetry at the stacking interface. There is a conformational exchange in the millisecond time scale involving a swapping motion between two bases of the six-guanine tract. Our results not only add to the understanding of how the G-quadruplex formation in human minisatellite leads to genetic instability but also address the fundamental questions regarding stacking of G-quadruplexes and how a long continuous G-tract participates in the structure and conformational dynamics of G-quadruplexes."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.org/dc/terms/identifier | "doi:10.1021/ja4125274"xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/author | "Nicolas A."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/author | "Adrian M."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/author | "Heddi B."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/author | "Phan A.T."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/author | "Ang D.J."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/author | "Lech C.J."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/name | "J Am Chem Soc"xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/pages | "6297-6305"xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/title | "Structure and conformational dynamics of a stacked dimeric G-quadruplex formed by the human CEB1 minisatellite."xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/24742225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24742225 |
| http://purl.uniprot.org/citations/24742225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A221SLY6-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_B3KSA4-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A1B1H4K9-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A222UBG1-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A222UBI2-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A222UBJ3-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A222UBK0-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A222UBK6-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |
| http://purl.uniprot.org/uniprot/#_A0A222UBK9-mappedCitation-24742225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24742225 |