| http://purl.uniprot.org/citations/24742674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24742674 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelet-activating factor (PAF), a potent proinflammatory lipid mediator, is synthesized rapidly in response to extracellular stimuli by the activation of acetyl-CoA:lyso-PAF acetyltransferase (lyso-PAFAT). We have reported previously that lyso-PAFAT activity is enhanced in three distinct ways in mouse macrophages: rapid activation (30 s) after PAF stimulation and minutes to hours after LPS stimulation. Lysophosphatidylcholine acyltransferase 2 (LPCAT2) was later identified as a Ca(2+)-dependent lyso-PAFAT. However, the mechanism of rapid lyso-PAFAT activation within 30 s has not been elucidated. Here we show a new signaling pathway for rapid biosynthesis of PAF that is mediated by phosphorylation of LPCAT2 at Ser-34. Stimulation by either PAF or ATP resulted in PKCα-mediated phosphorylation of LPCAT2 to enhance lyso-PAFAT activity and rapid PAF production. Biochemical analyses showed that the phosphorylation of Ser-34 resulted in augmentation of Vmax with minimal Km change. Our results offer an answer for the previously unknown mechanism of rapid PAF production."xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.558874"xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/author | "Morimoto R."xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/author | "Shindou H."xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/author | "Tarui M."xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/pages | "15566-15576"xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/title | "Rapid production of platelet-activating factor is induced by protein kinase Calpha-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein."xsd:string |
| http://purl.uniprot.org/citations/24742674 | http://purl.uniprot.org/core/volume | "289"xsd:string |
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