| http://purl.uniprot.org/citations/24746817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24746817 | http://www.w3.org/2000/01/rdf-schema#comment | "Sterile inflammation triggered by endogenous factors is thought to contribute to the pathogenesis of acute and chronic inflammatory diseases. Here, we demonstrate that apoptosis-deficient mutants spontaneously develop a necrosis-driven systemic immune response in Drosophila and provide an in vivo model for studying the organismal response to sterile inflammation. Metabolomic analysis of hemolymph from apoptosis-deficient mutants revealed increased sarcosine and reduced S-adenosyl-methionine (SAM) levels due to glycine N-methyltransferase (Gnmt) upregulation. We showed that Gnmt was elevated in response to Toll activation induced by the local necrosis of wing epidermal cells. Necrosis-driven inflammatory conditions induced dFoxO hyperactivation, leading to an energy-wasting phenotype. Gnmt was cell-autonomously upregulated by dFoxO in the fat body as a possible rheostat for controlling energy loss, which functioned during fasting as well as inflammatory conditions. We propose that the dFoxO-Gnmt axis is essential for the maintenance of organismal SAM metabolism and energy homeostasis."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2014.03.046"xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Miura M."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Soga T."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Takeishi A."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Kuranaga E."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Obata F."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Ming M."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/author | "Tomioka K."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/pages | "821-833"xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/title | "Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis."xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/24746817 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24746817 |
| http://purl.uniprot.org/citations/24746817 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24746817 |
| http://purl.uniprot.org/uniprot/Q9XYF4#attribution-BF24C81ED628D21F837C7C3FF97A79E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24746817 |
| http://purl.uniprot.org/uniprot/Q9VG42#attribution-BF24C81ED628D21F837C7C3FF97A79E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24746817 |
| http://purl.uniprot.org/uniprot/Q9U8R4#attribution-BF24C81ED628D21F837C7C3FF97A79E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24746817 |
| http://purl.uniprot.org/uniprot/Q7KLI1#attribution-BF24C81ED628D21F837C7C3FF97A79E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24746817 |
| http://purl.uniprot.org/uniprot/Q961K2#attribution-BF24C81ED628D21F837C7C3FF97A79E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24746817 |
| http://purl.uniprot.org/uniprot/Q8IGS5#attribution-BF24C81ED628D21F837C7C3FF97A79E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24746817 |
| http://purl.uniprot.org/uniprot/A1ZAZ2#attribution-BF24C81ED628D21F837C7C3FF97A79E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24746817 |