| http://purl.uniprot.org/citations/24747529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24747529 | http://www.w3.org/2000/01/rdf-schema#comment | "Knowledge of the mechanisms involved in the radiation response is critical for developing interventions to mitigate radiation-induced injury to normal tissues. Exposure to radiation leads to increased oxidative stress, DNA-damage, genomic instability and inflammation. The transcription factor CCAAT/enhancer binding protein delta (Cebpd; C/EBPδ is implicated in regulation of these same processes, but its role in radiation response is not known. We investigated the role of C/EBPδ in radiation-induced hematopoietic and intestinal injury using a Cebpd knockout mouse model. Cebpd-/-mice showed increased lethality at 7.4 and 8.5 Gy total-body irradiation (TBI), compared to Cebpd+/+ mice. Two weeks after a 6 Gy dose of TBI, Cebpd-/-mice showed decreased recovery of white blood cells, neutrophils, platelets, myeloid cells and bone marrow mononuclear cells, decreased colony-forming ability of bone marrow progenitor cells, and increased apoptosis of hematopoietic progenitor and stem cells compared to Cebpd+/+ controls. Cebpd-/-mice exhibited a significant dose-dependent decrease in intestinal crypt survival and in plasma citrulline levels compared to Cebpd+/+ mice after exposure to radiation. This was accompanied by significantly decreased expression of γ-H2AX in Cebpd-/-intestinal crypts and villi at 1 h post-TBI, increased mitotic index at 24 h post-TBI, and increase in apoptosis in intestinal crypts and stromal cells of Cebpd-/-compared to Cebpd+/+ mice at 4 h post-irradiation. This study uncovers a novel biological function for C/EBPδ in promoting the response to radiation-induced DNA-damage and in protecting hematopoietic and intestinal tissues from radiation-induced injury."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0094967"xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Chang J."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Shao L."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Pathak R."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Sterneck E."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Boerma M."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Hauer-Jensen M."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Hendrickson H."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/author | "Pawar S.A."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/pages | "e94967"xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/title | "C/EBPdelta deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury."xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24747529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24747529 |
| http://purl.uniprot.org/citations/24747529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24747529 |
| http://purl.uniprot.org/uniprot/#_B9EIA9-mappedCitation-24747529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24747529 |
| http://purl.uniprot.org/uniprot/#_Q00322-mappedCitation-24747529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24747529 |
| http://purl.uniprot.org/uniprot/#_Q3UE64-mappedCitation-24747529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24747529 |