| http://purl.uniprot.org/citations/24749077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24749077 | http://www.w3.org/2000/01/rdf-schema#comment | "Throughout their journey to forming new individuals, germline stem cells must remain totipotent, particularly by maintaining a specific chromatin structure. However, the place epigenetic factors occupy in this process remains elusive. So far, "sensitization" of chromatin by modulation of histone arrangement and/or content was believed to facilitate transcription-factor-induced germ cell reprogramming. Here, we demonstrate that the combined reduction of two epigenetic factors suffices to reprogram C. elegans germ cells. The histone H3K4 demethylase SPR-5/LSD1 and the chromatin remodeler LET-418/Mi2 function together in an early process to maintain germ cell status and act as a barrier to block precocious differentiation. This epigenetic barrier is capable of limiting COMPASS-mediated H3K4 methylation, because elevated H3K4me3 levels correlate with germ cell reprogramming in spr-5; let-418 mutants. Interestingly, germ cells deficient for spr-5 and let-418 mainly reprogram as neurons, suggesting that neuronal fate might be the first to be derepressed in early embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2014.02.007"xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/author | "Muller F."xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/author | "Wicky C."xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/author | "Kaser-Pebernard S."xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/pages | "547-559"xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/title | "LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells."xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/24749077 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24749077 |
| http://purl.uniprot.org/citations/24749077 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24749077 |
| http://purl.uniprot.org/uniprot/#_G5EBZ4-mappedCitation-24749077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24749077 |
| http://purl.uniprot.org/uniprot/#_P90916-mappedCitation-24749077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24749077 |
| http://purl.uniprot.org/uniprot/#_Q21502-mappedCitation-24749077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24749077 |
| http://purl.uniprot.org/uniprot/#_O17695-mappedCitation-24749077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24749077 |
| http://purl.uniprot.org/uniprot/#_Q9XWP6-mappedCitation-24749077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24749077 |
| http://purl.uniprot.org/uniprot/Q21502 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24749077 |
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| http://purl.uniprot.org/uniprot/O17695 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24749077 |
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| http://purl.uniprot.org/uniprot/G5EBZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24749077 |