| http://purl.uniprot.org/citations/24754922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24754922 | http://www.w3.org/2000/01/rdf-schema#comment | "Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of dominant and sporadic Parkinson's disease (PD), a common neurodegenerative disorder. Yeast-two-hybrid screening using human LRRK2 kinase domain as bait identified microtubule associated protein 1B (MAP1B) as a LRRK2 interactor. The interacting domains were LRRK2 kinase and the light chain portion of MAP1B (LC1). LRRK2 + LC1 interaction resulted in LRRK2 kinase inhibition. LRRK2 mutants (R1441C, G2019S and I2020T) exhibited decreased endogenous LC1 expression and its co-expression with LC1 rescued LRRK2 mutant-mediated toxicity. This study presented the first data on the effects of LRRK2 + LC1 interaction and also suggested that LCI possibly rescued LRRK2 mutant-induced cytotoxicity by inhibiting LRRK2 kinase activity. Compounds that upregulate LC1 expression may therefore hold therapeutic potential for LRRK2-linked diseases."xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.org/dc/terms/identifier | "doi:10.1186/1756-6606-7-29"xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/author | "Angeles D.C."xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/author | "Chua L.L."xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/author | "Tan E.K."xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/author | "Chan S.L."xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/name | "Mol Brain"xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/pages | "29"xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/title | "MAP1B rescues LRRK2 mutant-mediated cytotoxicity."xsd:string |
| http://purl.uniprot.org/citations/24754922 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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