| http://purl.uniprot.org/citations/24755855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24755855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24755855 | http://www.w3.org/2000/01/rdf-schema#comment | "RIG-I is a pivotal cytoplasmic sensor that recognizes different species of viral RNAs. This recognition leads to activation of the transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and innate antiviral response. In this study, we identified the TRIM family protein TRIM4 as a positive regulator of RIG-I-mediated IFN induction. Overexpression of TRIM4 potentiated virus-triggered activation of IRF3 and NF-κB, as well as IFN-β induction, whereas knockdown of TRIM4 had opposite effects. Mechanistically, TRIM4 associates with RIG-I and targets it for K63-linked polyubiquitination. Our findings demonstrate that TRIM4 is an important regulator of the virus-induced IFN induction pathways by mediating RIG-I for K63-linked ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.org/dc/terms/identifier | "doi:10.1093/jmcb/mju005"xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.org/dc/terms/identifier | "doi:10.1093/jmcb/mju005"xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Shu H.B."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Shu H.B."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Hu M.M."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Hu M.M."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Mao A.P."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/author | "Mao A.P."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/name | "J. Mol. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/name | "J. Mol. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/pages | "154-163"xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/pages | "154-163"xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/title | "TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/title | "TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/24755855 | http://purl.uniprot.org/core/volume | "6"xsd:string |