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| http://purl.uniprot.org/citations/24756834 | http://www.w3.org/2000/01/rdf-schema#comment | "It is known that microRNA-219 (miR-219) expression is downregulated in medulloblastoma. In the present study, we investigated the expression, targets and functional effects of miR-219 in D283-MED medulloblastoma cells. We first demonstrated that miR-219 not only inhibits proliferation, but also suppresses the invasion and migration of D283-MED cells. Moreover, the knockdown of miR-219 promoted the proliferation, migration and invasion of the D283-MED cells. Secondly, we predicted that miR-219 targets the 3' untranslated region (3'UTR) of CD164 and orthodenticle homeobox 2 (OTX2) and then confirmed that it significantly downregulated the protein expression of CD164 and OTX2 in D283-MED cells. Finally, we demonstrated that the proliferation, invasion and migration of D283-MED cells were promoted by theectopic expression of CD164. These results indicate that miR-219 suppresses the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. The results also suggest that miR-219 may serve as a potential therapeutic agent for medulloblastoma."xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm.2014.1749"xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/author | "Tan W."xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/author | "Lu D.L."xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/author | "Shi J.A."xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/pages | "237-243"xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/title | "miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164."xsd:string |
| http://purl.uniprot.org/citations/24756834 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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