| http://purl.uniprot.org/citations/24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24757053 | http://www.w3.org/2000/01/rdf-schema#comment | "Mossy fiber termini in the hippocampus accumulate Zn(2+), which is released with glutamate from synaptic vesicles upon neural excitation. Understanding the spatiotemporal regulation of mobile Zn(2+) at the synaptic level is challenging owing to the difficulty of visualizing Zn(2+) at individual synapses. Here we describe the use of zinc-responsive fluorescent probes together with two-photon microscopy to image Zn(2+) dynamics mediated by NMDA receptor-dependent long-term potentiation induction at single mossy fiber termini of dentate gyrus neurons in adult mouse hippocampal slices. The membrane-impermeant fluorescent Zn(2+) probe, 6-CO2H-ZAP4, was loaded into presynaptic vesicles in hippocampal mossy fiber termini upon KCl-induced depolarization, which triggers subsequent endocytosis and vesicular restoration. Local tetanic stimulation decreased the Zn(2+) signal observed at individual presynaptic sites, indicating release of the Zn(2+) from vesicles in synaptic potentiation. This synapse-level two-photon Zn(2+) imaging method enables monitoring of presynaptic Zn(2+) dynamics for improving the understanding of physiological roles of mobile Zn(2+) in regular and aberrant neurologic function."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1405154111"xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Okamoto K."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Khan M."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Lippard S.J."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Roder J.C."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Georgiou J."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Goldsmith C.R."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/author | "Luyben T.T."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/pages | "6786-6791"xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/title | "Two-photon imaging of Zn2+ dynamics in mossy fiber boutons of adult hippocampal slices."xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24757053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24757053 |
| http://purl.uniprot.org/citations/24757053 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24757053 |
| http://purl.uniprot.org/uniprot/#_P97441-mappedCitation-24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24757053 |
| http://purl.uniprot.org/uniprot/#_Q3UN07-mappedCitation-24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24757053 |
| http://purl.uniprot.org/uniprot/#_Q3TMQ7-mappedCitation-24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24757053 |
| http://purl.uniprot.org/uniprot/#_Q6NZC3-mappedCitation-24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24757053 |
| http://purl.uniprot.org/uniprot/#_S4R2M0-mappedCitation-24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24757053 |
| http://purl.uniprot.org/uniprot/#_S4R2S4-mappedCitation-24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24757053 |
| http://purl.uniprot.org/uniprot/#_S4R166-mappedCitation-24757053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24757053 |