| http://purl.uniprot.org/citations/24763381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24763381 | http://www.w3.org/2000/01/rdf-schema#comment | "microRNAs function in diverse developmental and physiological processes by regulating target gene expression at the post-transcriptional level. ALG-1 is one of two Caenorhabditis elegans Argonautes (ALG-1 and ALG-2) that together are essential for microRNA biogenesis and function. Here, we report the identification of novel antimorphic (anti) alleles of ALG-1 as suppressors of lin-28(lf) precocious developmental phenotypes. The alg-1(anti) mutations broadly impair the function of many microRNAs and cause dosage-dependent phenotypes that are more severe than the complete loss of ALG-1. ALG-1(anti) mutant proteins are competent for promoting Dicer cleavage of microRNA precursors and for associating with and stabilizing microRNAs. However, our results suggest that ALG-1(anti) proteins may sequester microRNAs in immature and functionally deficient microRNA Induced Silencing Complexes (miRISCs), and hence compete with ALG-2 for access to functional microRNAs. Immunoprecipitation experiments show that ALG-1(anti) proteins display an increased association with Dicer and a decreased association with AIN-1/GW182. These findings suggest that alg-1(anti) mutations impair the ability of ALG-1 miRISC to execute a transition from Dicer-associated microRNA processing to AIN-1/GW182 associated effector function, and indicate an active role for ALG/Argonaute in mediating this transition."xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1004286"xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/author | "Ambros V."xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/author | "Hammell C.M."xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/author | "Simard M.J."xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/author | "Zinovyeva A.Y."xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/author | "Bouasker S."xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/pages | "e1004286"xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/title | "Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression."xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/24763381 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24763381 |
| http://purl.uniprot.org/citations/24763381 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24763381 |
| http://purl.uniprot.org/uniprot/G5EES3#attribution-B61ADE1AF567E4FEA74277ABE585E3D7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/#_P34529-mappedCitation-24763381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/#_G5EES3-mappedCitation-24763381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/#_G5EGR6-mappedCitation-24763381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/#_Q17740-mappedCitation-24763381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/P34529 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/Q17740 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/G5EGR6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24763381 |
| http://purl.uniprot.org/uniprot/G5EES3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24763381 |