| http://purl.uniprot.org/citations/24766216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24766216 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear transporter exportin-1 (XPO1) is highly expressed in mantle cell lymphoma (MCL) cells, and is believed to be associated with the pathogenesis of this disease. XPO1-selective inhibitors of nuclear export (SINE) compounds have been shown to induce apoptosis in MCL cells. Given that p53 is a cargo protein of XPO1, we sought to determine the significance of p53 activation through XPO1 inhibition in SINE-induced apoptosis of MCL cells. We investigated the prognostic impact of XPO1 expression in MCL cells using Oncomine analysis. The significance of p53 mutational/functional status on sensitivity to XPO1 inhibition in cell models and primary MCL samples, and the functional role of p53-mediated apoptosis signaling, were also examined. Increased XPO1 expression was associated with poor prognosis in MCL patients. The XPO1 inhibitor KPT-185 induced apoptosis in MCL cells through p53-dependent and -independent mechanisms, and p53 status was a critical determinant of its apoptosis induction. The KPT-185-induced, p53-mediated apoptosis in the MCL cells occurred in a transcription-dependent manner. Exportin-1 appears to influence patient survival in MCL, and the SINE XPO1 antagonist KPT-185 effectively activates p53-mediated transcription and apoptosis, which would provide a novel strategy for the therapy of MCL."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.12430"xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Yoshimura M."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Kojima K."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Andreeff M."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Ruvolo V."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Neelapu S.S."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Yokoo M."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Kauffman M."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "McDonnell T.J."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Kwak L.W."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Shacham S."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Tabe Y."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Quintas-Cardama A."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Ishizawa J."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/author | "Dilip A."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/pages | "795-801"xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/title | "Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/24766216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24766216 |
| http://purl.uniprot.org/citations/24766216 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24766216 |