| http://purl.uniprot.org/citations/24767989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24767989 | http://www.w3.org/2000/01/rdf-schema#comment | "Vesicular H(+)-ATPases and ClC-chloride transporters are described to acidify intracellular compartments, which also express the highly conserved Na(+)/H(+) exchangers NHE6, NHE7, and NHE9. Mutations of these exchangers cause autism-spectrum disorders and neurodegeneration. NHE6, NHE7, and NHE9 are hypothesized to exchange cytosolic K(+) for H(+) and alkalinize vesicles, but this notion has remained untested in K(+) because their intracellular localization prevents functional measurements. Using proton-killing techniques, we selected a cell line that expresses wild-type NHE7 at the plasma membrane, enabling measurement of the exchanger's transport parameters. We found that NHE7 transports Li(+) and Na(+), but not K(+), is nonreversible in physiological conditions and is constitutively activated by cytosolic H(+). Therefore, NHE7 acts as a proton-loading transporter rather than a proton leak. NHE7 mediates an acidification of intracellular vesicles that is additive to that of V-ATPases and that accelerates endocytosis. This study reveals an unexpected function for vesicular Na(+)/H(+) exchangers and provides clues for understanding NHE-linked neurological disorders."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2014.03.054"xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Lacas-Gervais S."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Poet M."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Monet M."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Brau F."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Feliciangeli S."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Counillon L."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Milosavljevic N."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/author | "Lena I."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/pages | "689-696"xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/title | "The intracellular Na(+)/H(+) exchanger NHE7 effects a Na(+)-coupled, but not K(+)-coupled proton-loading mechanism in endocytosis."xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/24767989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24767989 |
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| http://purl.uniprot.org/uniprot/A0A087WXD1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24767989 |