| http://purl.uniprot.org/citations/24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24768535 | http://www.w3.org/2000/01/rdf-schema#comment | "In response to DNA damage, PCNA is mono-ubiquitinated and triggers translesion DNA synthesis (TLS) by recruiting polymerase-η. However, it remained unknown how error-prone TLS is turned off after DNA lesion bypass to prevent mutagenesis. Here we showed that ISG15 modification (ISGylation) of PCNA plays a key role in TLS termination. Upon UV irradiation, EFP, an ISG15 E3 ligase, bound to mono-ubiquitinated PCNA and promoted its ISGylation. ISGylated PCNA then tethered USP10 for deubiquitination and in turn the release of polymerase-η from PCNA. Eventually, PCNA was deISGylated by UBP43 for reloading of replicative DNA polymerases and resuming normal DNA replication. However, ISGylation-defective Lys-to-Arg mutations in PCNA or knockdown of any of ISG15, EFP, or USP10 led to persistent recruitment of mono-ubiquitinated PCNA and polymerase-η to nuclear foci, causing an increase in mutation frequency. These findings establish a crucial role of PCNA ISGylation in termination of error-prone TLS for preventing excessive mutagenesis."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.03.031"xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Yang S.W."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Chung C.H."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Seol J.H."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Park J.M."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Jeon Y.J."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Yu K.R."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/author | "Ka S.H."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/pages | "626-638"xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/title | "Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis."xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/24768535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24768535 |
| http://purl.uniprot.org/citations/24768535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24768535 |
| http://purl.uniprot.org/uniprot/#_Q07864-mappedCitation-24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24768535 |
| http://purl.uniprot.org/uniprot/#_Q14258-mappedCitation-24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24768535 |
| http://purl.uniprot.org/uniprot/#_Q15004-mappedCitation-24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24768535 |
| http://purl.uniprot.org/uniprot/#_Q15054-mappedCitation-24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24768535 |
| http://purl.uniprot.org/uniprot/#_B4DUA2-mappedCitation-24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24768535 |
| http://purl.uniprot.org/uniprot/#_P49005-mappedCitation-24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24768535 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-24768535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24768535 |