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| http://purl.uniprot.org/citations/24769494 | http://www.w3.org/2000/01/rdf-schema#comment | "Nck adapter proteins link receptor and receptor-associated tyrosine kinases with proteins implicated in the regulation of the actin cytoskeleton. Nck is involved in a multitude of receptor-initiated signaling pathways and its physiological role thus covers aspects of tissue development and homeostasis, malignant transformation/invasiveness of tumour cells and also immune cell function. In T cells, changes of cell polarity and morphology associated with cellular activation and effector function crucially rely on the T cell receptor-mediated recruitment and activation of different actin-regulatory proteins to orchestrate and drive cytoskeletal reorganization at the immunological synapse. In a former approach to determine the interactome of Nck in human T cells, we identified the adapter protein ADAP as a Nck-interacting protein. This adhesion and degranulation-promoting adapter protein had already been implicated in the inside-out activation of integrins. Employing co-immunoprecipitations, we demonstrate that both Nck family members Nck1 and Nck2 coprecipitate with ADAP. Specifically, Nck interacts via its Src homology 2 domain with phosphorylated tyrosine Y595DDV and Y651DDV sites of ADAP. Moreover, we show that endogenous ADAP is phosphorylated in primary human T cell blasts and thus associates with Nck. At the functional level, ADAP and Nck adapter proteins cooperatively facilitate T cell adhesion to the LFA-1 ligand ICAM-1. Our data indicate that the ADAP/Nck complex might provide a means to link integrin activation with the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2014.03.017"xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/author | "Kliche S."xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/author | "Kabelitz D."xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/author | "Janssen O."xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/author | "Lettau M."xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/pages | "72-79"xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/title | "The adapter proteins ADAP and Nck cooperate in T cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/24769494 | http://purl.uniprot.org/core/volume | "60"xsd:string |
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