| http://purl.uniprot.org/citations/24777060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24777060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24777060 | http://www.w3.org/2000/01/rdf-schema#comment | "Celiac disease is a T cell-mediated disease induced by dietary gluten, a component of which is gliadin. 95% of individuals with celiac disease carry the HLA (human leukocyte antigen)-DQ2 locus. Here we determined the T-cell receptor (TCR) usage and fine specificity of patient-derived T-cell clones specific for two epitopes from wheat gliadin, DQ2.5-glia-α1a and DQ2.5-glia-α2. We determined the ternary structures of four distinct biased TCRs specific for those epitopes. All three TCRs specific for DQ2.5-glia-α2 docked centrally above HLA-DQ2, which together with mutagenesis and affinity measurements provided a basis for the biased TCR usage. A non-germline encoded arginine residue within the CDR3β loop acted as the lynchpin within this common docking footprint. Although the TCRs specific for DQ2.5-glia-α1a and DQ2.5-glia-α2 docked similarly, their interactions with the respective gliadin determinants differed markedly, thereby providing a basis for epitope specificity."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2817"xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2817"xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Schweizer J."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Schweizer J."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Reid H.H."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Reid H.H."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Mearin M.L."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Mearin M.L."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Anderson R.P."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Anderson R.P."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Beringer D.X."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Beringer D.X."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Koning F."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Koning F."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Kooy-Winkelaar Y."xsd:string |
| http://purl.uniprot.org/citations/24777060 | http://purl.uniprot.org/core/author | "Kooy-Winkelaar Y."xsd:string |