Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/24778018http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24778018http://www.w3.org/2000/01/rdf-schema#comment"

Background/aim

NOTCH-regulated ankyrin repeat protein (NRARP) has been implicated in crosstalk between NOTCH and wingless-type mouse mammary tumor virus integration site (WNT) signals during development. Our study aimed to clarify its role in breast cancer cells.

Materials and methods

Public microarray data were used to analyze gene expression in human and rat breast cancer. A short interfering RNA was introduced into MCF7 and T47D human breast cancer cells for NRARP silencing. Gene expression was analyzed by quantitative polymerase chain reaction.

Results

The NRARP transcript was commonly overexpressed in various rat mammary cancer models. In addition, a subset of human breast cancer also expressed high levels of NRARP transcript, which correlated positively with up-regulation of cell proliferation-related genes. Silencing of NRARP suppressed the growth of MCF7 and T47D cells and lowered the expression of cell cycle-related genes in MCF7 cells.

Conclusion

NRARP may stimulate cell proliferation in human breast cancer."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/author"Nishimura M."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/author"Shimada Y."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/author"Okutani T."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/author"Imaoka T."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/author"Daino K."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/author"Iizuka D."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/pages"2165-2171"xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/title"Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation."xsd:string
http://purl.uniprot.org/citations/24778018http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/24778018http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24778018
http://purl.uniprot.org/citations/24778018http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24778018
http://purl.uniprot.org/uniprot/#_Q7Z6K4-mappedCitation-24778018http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24778018
http://purl.uniprot.org/uniprot/Q7Z6K4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24778018