| http://purl.uniprot.org/citations/24778262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24778262 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular Ca(2+) transient is crucial in initiating the differentiation of mesenchymal cells into chondrocytes, but whether voltage-gated Ca(2+) channels are involved remains uncertain. Here, we show that the T-type voltage-gated Ca(2+) channel Cav3.2 is essential for tracheal chondrogenesis. Mice lacking this channel (Cav3.2(-/-)) show congenital tracheal stenosis because of incomplete formation of cartilaginous tracheal support. Conversely, Cav3.2 overexpression in ATDC5 cells enhances chondrogenesis, which could be blunted by both blocking T-type Ca(2+) channels and inhibiting calcineurin and suggests that Cav3.2 is responsible for Ca(2+) influx during chondrogenesis. Finally, the expression of sex determination region of Y chromosome (SRY)-related high-mobility group-Box gene 9 (Sox9), one of the earliest markers of committed chondrogenic cells, is reduced in Cav3.2(-/-) tracheas. Mechanistically, Ca(2+) influx via Cav3.2 activates the calcineurin/nuclear factor of the activated T-cell (NFAT) signaling pathway, and a previously unidentified NFAT binding site is identified within the mouse Sox9 promoter using a luciferase reporter assay and gel shift and ChIP studies. Our findings define a previously unidentified mechanism that Ca(2+) influx via the Cav3.2 T-type Ca(2+) channel regulates Sox9 expression through the calcineurin/NFAT signaling pathway during tracheal chondrogenesis."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1323112111"xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/author | "Lin S.S."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/author | "Campbell K.P."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/author | "Smith R.J."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/author | "Lee K.R."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/author | "Tzeng B.H."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/pages | "E1990-8"xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/title | "Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage."xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24778262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24778262 |
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