| http://purl.uniprot.org/citations/24778443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24778443 | http://www.w3.org/2000/01/rdf-schema#comment | "Abs play a significant role in protection against the intracellular bacterium Salmonella Typhi. In this article, we investigated how long-term protective IgM responses can be elicited by a S. Typhi outer-membrane protein C- and F-based subunit vaccine (porins). We found that repeated Ag exposure promoted a CD4(+) T cell-dependent germinal center reaction that generated mutated IgM-producing B cells and was accompanied by a strong expansion of IFN-γ-secreting T follicular helper cells. Genetic ablation of individual cytokine receptors revealed that both IFN-γ and IL-17 are required for optimal germinal center reactions and production of porin-specific memory IgM(+) B cells. However, more profound reduction of porin-specific IgM B cell responses in the absence of IFN-γR signaling indicated that this cytokine plays a dominant role. Importantly, mutated IgM mAbs against porins exhibited bactericidal capacity and efficiently augmented S. Typhi clearance. In conclusion, repeated vaccination with S. Typhi porins programs type I T follicular helper cell responses that contribute to the diversification of B cell memory and promote the generation of protective IgM Abs."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1302526"xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Chai Q."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Ludewig B."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Cervantes-Barragan L."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Gil-Cruz C."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Regen T."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Onder L."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Isibasi A."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Scandella E."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Lopez-Macias C."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Pastelin-Palacios R."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Perez-Shibayama C."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/author | "Hisaki E."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/pages | "5192-5200"xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/title | "IFN-gamma-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi."xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24778443 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24778443 |
| http://purl.uniprot.org/citations/24778443 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24778443 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-24778443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24778443 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-24778443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24778443 |