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| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/2478623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2478623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2478623 | http://www.w3.org/2000/01/rdf-schema#comment | "The HLA-Aw19 complex consists of a number of serologically cross-reactive Ag (i.e., A29, A30, A31, A32, and Aw33) which exhibit an epitope shared by HLA-B and -C proteins. To investigate the structural basis for these serologic cross-reactivities, we have cloned and determined the nucleotide sequences for A30, A31, and Aw33, and compared the predicted amino acid sequences with those already available for A29, A32, and other class I allelic products. All alleles of the Aw19 group contained A-locus-specific sequences, exhibiting "A-ness." The structural similarities between Aw19 polypeptides were found in the alpha 1 and alpha 2 domains, where shared amino acid residues were identified that correlated with observed serological reactivity patterns. Seven Aw19-specific nucleotides were found. Two of these were silent substitutions, but the remaining five resulted in Aw19-specific amino acid residues. Each of the HLA-A alleles can be classified into one of the five serologically cross-reacting groups. In the Aw19 group, the alleles A29, A31, A32, and Aw33 are closely related serologically as well as genetically whereas A30 probably belongs to the A1/A3/A11 group. The similarity between A30 and the other Aw19 alleles may have resulted from two independent gene conversions affecting exons 2 and 3. Additional mutations or gene conversion-like events in A30 were also noted. It is postulated that gene conversions have played a significant role in the divergence of the Aw19 alleles. However, each serologically cross-reactive Aw19 allotype appears to have arisen directly from a common ancestral allele. A30 was the only exception, and this allele may represent an unusual allotype, which is subject to a high rate of genetic changes, as is seen in the H-2Kb gene of the mouse."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Yang S.Y."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Yang S.Y."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Trapani J.A."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Trapani J.A."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Dupont B."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Dupont B."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Allopenna J."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/author | "Allopenna J."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/pages | "3371-3378"xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/pages | "3371-3378"xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/title | "Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/title | "Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30."xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/volume | "143"xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://purl.uniprot.org/core/volume | "143"xsd:string |
| http://purl.uniprot.org/citations/2478623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2478623 |
| http://purl.uniprot.org/citations/2478623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2478623 |