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http://purl.uniprot.org/citations/24786389http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24786389http://www.w3.org/2000/01/rdf-schema#comment"

Background

Pre-eclampsia, a hypertensive disorder of pregnancy is the main cause of fetal and maternal morbidity and mortality. Growing evidences suggest that placental oxidative stress involves in the pathogenesis of pre-eclampsia. The HSP70 is a novel marker of oxidative stress which binds with high avidity to LOX-1. The aim of this study was to evaluate the co-expression of HSP70 and LOX-1 in the placental tissues of normotensive and pre-eclamptic pregnancies.

Materials and methods

The placental tissues were collected from 35 healthy women with normal pregnancies and 33 women with pre-eclampsia disorder. Expression of HSP70 and LOX-1 on the placental tissues was examined by using immunohistochemistry technique. The intensity of the molecules' expression was determined by semi-quantitative scoring.

Results

The 34.3% and 37.1% of the healthy women did not express the HSP70 and LOX-1 on their placenta, respectively. All pre-eclamptic patients expressed HSP70 and LOX-1 with various scores. Indeed, the majority of the pre-eclamptic subjects had ≥3+ scores of the expression of HSP70 and LOX-1 on their placenta (60.6% and 66.7%, respectively). The percentage of the ≥3+ scores of the expression of HSP70 and LOX-1 was significantly higher in patients than those in healthy women (p<0.0001 for both). Similarly, the majority of the pre-eclamptic subjects had ≥3+ scores of the co-expression of HSP70 and LOX-1 molecules (57.6%) which was significantly higher in patients than those in control group (p=0.0001).

Conclusions

These results showed higher expression of HSP70 and LOX-1 in the placental tissues of pre-eclampsia patients which represent the possible contribution of these molecules in the disease pathogenesis. Further studies need to clarify their role in the pathogenesis of preeclampsia disorder."xsd:string
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http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/author"Jafarzadeh A."xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/author"Mousavinasab N."xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/author"Sheikhi A."xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/author"Ganji H.B."xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/author"Rahmanpour H."xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/author"Razdar S."xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/name"Clin Exp Hypertens"xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/pages"128-135"xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/title"Higher expression of HSP70 and LOX-1 in the placental tissues of pre-eclampsia pregnancies."xsd:string
http://purl.uniprot.org/citations/24786389http://purl.uniprot.org/core/volume"37"xsd:string
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