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| http://purl.uniprot.org/citations/24788728 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia is a characteristic pathophysiological property of locally advanced solid tumors and a relevant factor of the tumor (patho-)physiome since it can promote tumor progression and resistance to therapy. Tumors alter their metabolic pathways to survive in nutrient and oxygen poor microenvironments by a process known as the "Warburg Effect." The current studies identify a novel tumor suppressor gene, termed oxidored nitro domain-containing protein 1 (NOR1) which alters hypoxia cellular response in nasopharyngeal carcinoma. NOR1 expression causes apoptosis of tumor cells in hypoxia by altering the expression of PDK1 expression and mitochondrial Bax-Bcl2 balance thus suppress tumor cell adaptation to hypoxia. Although the importance of hypoxia cellular response is well documented in tumor progression, this is the first demonstration of a human tumor suppressor which functions by regulating mitochondrial apoptotic pathways to suppress tumor survival in oxygen poor microenvironments."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-014-2072-9"xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/author | "Xiang B."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/author | "Zheng P."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/author | "Yi M."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/pages | "293-300"xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/title | "Expression of oxidored nitro domain-containing protein 1(NOR1) impairs nasopharyngeal carcinoma cells adaptation to hypoxia and inhibits PDK1 expression."xsd:string |
| http://purl.uniprot.org/citations/24788728 | http://purl.uniprot.org/core/volume | "393"xsd:string |
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