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http://purl.uniprot.org/citations/24788730http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objectives

The aim of the study was to investigate the association of TNFα-induced protein 3 interacting with protein 1 (TNIP1) gene polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD) in a Han Chinese population.

Methods

A total of 656 BD patients, 961 VKH syndrome patients and 1534 healthy controls were included in this two-stage case control study. Seven SNPs, including rs17728338, rs7708392, rs10036748, rs3762999, rs999556, rs4958881 and rs3792783, belonging to TNIP1 were genotyped and analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The data were analyzed by using the χ2 or Fisher's exact test and corrected for multiple comparisons by the Bonferroni method.

Results

A significantly increased frequency of the GG genotype and a decreased frequency of the AG genotype of rs17728338 were found in VKH patients (Pc = 0.038 OR = 1.934, 95% CI  = 1.438 ∼ 2.601). No significant difference was noted in allele or genotype frequencies of rs7708392, rs10036748, rs3762999, rs999556, rs4958881 and rs3792783, between VKH patients and healthy controls (Pc>0.05). No significant difference was noted in allele or genotype frequencies of the tested 7 SNPs between BD patients and healthy controls. Analysis of extraocular clinical findings, did not reveal an association of the TNIP1 gene polymorphisms with BD or VKH syndrome subgroups.

Conclusion

A TNIP1 polymorphism may be a risk factor for VKH syndrome in Han Chinese."xsd:string
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http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/author"Hou S."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/author"Fang J."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/author"Jia Y."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/author"Shi Y."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/author"Zhou Y."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/author"Yang P."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/author"Kijlstra A."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/pages"e95573"xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/title"Association of a TNIP1 polymorphism with Vogt-Koyanagi-Harada syndrome but not with ocular Behcet's disease in Han Chinese."xsd:string
http://purl.uniprot.org/citations/24788730http://purl.uniprot.org/core/volume"9"xsd:string
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