| http://purl.uniprot.org/citations/24790147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24790147 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class I polymorphisms are known to influence outcomes in a number of infectious diseases, cancers, and inflammatory diseases. Human MHC class I H chains are encoded by the HLA-A, HLA-B, and HLA-C genes. These genes are highly polymorphic, with the HLA-B locus being the most variable. Each HLA class I protein binds to a distinct set of peptide Ags, which are presented to CD8(+) T cells. HLA-disease associations have been shown in some cases to link to the peptide-binding characteristics of individual HLA class I molecules. In this study, we show that polymorphisms at the HLA-B locus profoundly influence the assembly characteristics of HLA-B molecules and the stabilities of their peptide-deficient forms. In particular, dependence on the assembly factor tapasin is highly variable, with frequent occurrence of strongly tapasin-dependent or independent allotypes. Several polymorphic HLA-B residues located near the C-terminal end of the peptide are key determinants of tapasin-independent assembly. In vitro refolded forms of tapasin-independent allotypes assemble more readily with peptides compared to tapasin-dependent allotypes that belong to the same supertype, and, during refolding, reduced aggregation of tapasin-independent allotypes is observed. Paradoxically, in HIV-infected individuals, greater tapasin-independent HLA-B assembly confers more rapid progression to death, consistent with previous findings that some HLA-B allotypes shown to be tapasin independent are associated with rapid progression to multiple AIDS outcomes. Together, these findings demonstrate significant variations in the assembly of HLA-B molecules and indicate influences of HLA-B-folding patterns upon infectious disease outcomes."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1301670"xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Carrington M."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Geng J."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Wolinsky S.M."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Raghavan M."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Salam N."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Rizvi S.M."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Duggal P."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Bream J.H."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Martinson J."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/author | "Hussain S.K."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/pages | "4967-4976"xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/title | "Distinct assembly profiles of HLA-B molecules."xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24790147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24790147 |
| http://purl.uniprot.org/citations/24790147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24790147 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-24790147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24790147 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-24790147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24790147 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-24790147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24790147 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-24790147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24790147 |