| http://purl.uniprot.org/citations/24792116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24792116 | http://www.w3.org/2000/01/rdf-schema#comment | "Fate decisions in neural progenitor cells are orchestrated via multiple pathways, and the role of histone acetylation in these decisions has been ascribed to a general function promoting gene activation. Here, we show that the histone acetyltransferase (HAT) cofactor transformation/transcription domain-associated protein (Trrap) specifically regulates activation of cell-cycle genes, thereby integrating discrete cell-intrinsic programs of cell-cycle progression and epigenetic regulation of gene transcription in order to control neurogenesis. Deletion of Trrap impairs recruitment of HATs and transcriptional machinery specifically to E2F cell-cycle target genes, disrupting their transcription with consequent cell-cycle lengthening specifically within cortical apical neural progenitors (APs). Consistently, Trrap conditional mutants exhibit microcephaly because of premature differentiation of APs into intermediate basal progenitors and neurons, and overexpressing cell-cycle regulators in vivo can rescue these premature differentiation defects. These results demonstrate an essential and highly specific role for Trrap-mediated histone regulation in controlling cell-cycle progression and neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2014.04.001"xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Platzer M."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Groth M."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Yang Y.G."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Tapias A."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Huttner W."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Wang Z.Q."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Zhou Z.W."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Herceg Z."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/author | "Chong Z."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/pages | "632-643"xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/title | "Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions."xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/24792116 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24792116 |
| http://purl.uniprot.org/citations/24792116 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24792116 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU51-mappedCitation-24792116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24792116 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP23-mappedCitation-24792116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24792116 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP46-mappedCitation-24792116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24792116 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPL2-mappedCitation-24792116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24792116 |