| http://purl.uniprot.org/citations/24793650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24793650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24793650 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomerase is a large ribonucleoprotein complex minimally composed of a catalytic telomerase reverse transcriptase (TERT) and an RNA component (TR) that provides the template for telomeric DNA synthesis. However, it remains unclear how TERT and TR assemble into a functional telomerase. Here we report the crystal structure of the conserved regions 4 and 5 (CR4/5) of TR in complex with the TR-binding domain (TRBD) of TERT from the teleost fish Oryzias latipes. The structure shows that CR4/5 adopts an L-shaped three-way-junction conformation with its two arms clamping onto TRBD. Both the sequence and conformation of CR4/5 are required for the interaction. Our structural and mutational analyses suggest that the observed CR4/5-TRBD recognition is common to most eukaryotes, and CR4/5 in vertebrate TR might have a similar role in telomerase regulation as that of stem-loop IV in Tetrahymena TR."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2819"xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2819"xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Lei M."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Lei M."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Xue J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Xue J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Chen J.J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Chen J.J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Bley C.J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Bley C.J."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Brown A.F."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Brown A.F."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Rand D.P."xsd:string |
| http://purl.uniprot.org/citations/24793650 | http://purl.uniprot.org/core/author | "Rand D.P."xsd:string |