| http://purl.uniprot.org/citations/2479552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2479552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2479552 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factors bind with high affinity to specific binding proteins in extracellular fluids. To identify structural characteristics of IGF-binding proteins that might define their physiological roles, we determined the complete primary structure of a novel human IGF-binding protein (IGFBP-2) from a cloned cDNA. The cDNA encodes a 328 amino acid IGF-binding protein precursor which contains a 39-residue signal peptide. The mature 289 amino acid IGFBP-2 has a predicted Mr of 31,325. Chinese hamster ovary (CHO) cells stably transformed with the IGFBP-2 cDNA secreted a 36 kd protein which bound, with different affinities, IGFII and IGFI, but did not bind insulin. The predicted protein sequence of this IGF-binding protein shares extensive amino acid homology (greater than 85%) with the IGF-binding protein secreted by rat BRL-3A cells, but less than 40% homology with human IGFBP-1. Therefore IGFBP-2, and not IGFBP-1 as previously suggested, represents the human homologue of the rat BRL-BP (alpha IGFBP-2). Moreover, from alignment of the predicted protein sequences of IGFBP-1 and IGFBP-2, extensive conservation of the distribution of cysteine residues is observed. Although the overall amino acid homology shared by these proteins is not high, we suggest that they represent a family of structurally related human IGFBPs. Southern blot analysis of human DNA demonstrates that IGFBP-2 is encoded by a single-copy gene, different from that of IGFBP-1."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1989.tb08386.x"xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1989.tb08386.x"xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Binkert C."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Binkert C."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Heinrich G."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Heinrich G."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Landwehr J."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Landwehr J."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Mary J.L."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Mary J.L."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Schwander J."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/author | "Schwander J."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/pages | "2497-2502"xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/pages | "2497-2502"xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/title | "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/title | "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)."xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/2479552 | http://purl.uniprot.org/core/volume | "8"xsd:string |