| http://purl.uniprot.org/citations/24798879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24798879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24798879 | http://www.w3.org/2000/01/rdf-schema#comment | "Homologous recombination plays essential roles in mitotic DNA double strand break (DSB) repair and meiotic genetic recombination. In eukaryotes, RAD51 promotes the central homologous-pairing step during homologous recombination, but is not sufficient to overcome the reaction barrier imposed by nucleosomes. RAD54, a member of the ATP-dependent nucleosome remodeling factor family, is required to promote the RAD51-mediated homologous pairing in nucleosomal DNA. In higher eukaryotes, most nucleosomes form higher-ordered chromatin containing the linker histone H1. However, the mechanism by which RAD51/RAD54-mediated homologous pairing occurs in higher-ordered chromatin has not been elucidated. In this study, we found that a histone chaperone, Nap1, accumulates on DSB sites in human cells, and DSB repair is substantially decreased in Nap1-knockdown cells. We determined that Nap1 binds to RAD54, enhances the RAD54-mediated nucleosome remodeling by evicting histone H1, and eventually stimulates the RAD51-mediated homologous pairing in higher-ordered chromatin containing histone H1."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep04863"xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep04863"xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Ikura M."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Ikura M."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Kurumizaka H."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Kurumizaka H."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Matsuda R."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Matsuda R."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Kobayashi W."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Kobayashi W."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Ikura T."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Ikura T."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Machida S."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Machida S."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Osakabe A."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Osakabe A."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Tashiro S."xsd:string |
| http://purl.uniprot.org/citations/24798879 | http://purl.uniprot.org/core/author | "Tashiro S."xsd:string |