| http://purl.uniprot.org/citations/24802380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24802380 | http://www.w3.org/2000/01/rdf-schema#comment | "Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these populations ("TH-Vglut2 Class1") also expressed the dopamine transporter (DAT) gene while one did not ("TH-Vglut2 Class2"), and the remaining population did not express TH at all ("Vglut2-only"). TH is known to be expressed by a promoter which shows two phases of activation, a transient one early during embryonal development, and a later one which gives rise to stable endogenous expression of the TH gene. The transient phase is, however, not specific to catecholaminergic neurons, a feature taken to advantage here as it enabled Vglut2 gene targeting within all three A10 populations expressing this gene, thus creating a new conditional knockout. These knockout mice showed impairment in spatial memory function. Electrophysiological analyses revealed a profound alteration of oscillatory activity in the CA3 region of the hippocampus. In addition to identifying a novel role for Vglut2 in hippocampus function, this study points to the need for improved genetic tools for targeting of the diversity of subpopulations of the A10 area."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00429-014-0778-9"xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Morales M."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Nordenankar K."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Wallen-Mackenzie A."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Leao R.N."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Birgner C."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Schweizer N."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Mejia-Toiber J."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Smith-Anttila C.J."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/author | "Viereckel T."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/name | "Brain Struct Funct"xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/pages | "2171-2190"xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/title | "Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity."xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://purl.uniprot.org/core/volume | "220"xsd:string |
| http://purl.uniprot.org/citations/24802380 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24802380 |
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