| http://purl.uniprot.org/citations/24803542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24803542 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen synthase kinase 3 (GSK-3) is associated with several cellular systems, including immune response. Lithium, a widely used pharmacological treatment for bipolar disorder, is a GSK-3 inhibitor. GSK-3α is the predominant isoform in human neutrophils. In this study, we examined the effect of GSK-3 inhibition on the production of TNF-α by neutrophils. In the murine air pouch model of inflammation, lithium chloride (LiCl) amplified TNF-α release. In lipopolysaccharide-stimulated human neutrophils, GSK-3 inhibitors mimicked the effect of LiCl, each potentiating TNF-α release after 4 h, in a concentration-dependent fashion, by up to a 3-fold increase (ED50 of 1 mM for lithium). LiCl had no significant effect on cell viability. A positive association was revealed between GSK-3 inhibition and prolonged activation of the p38/MNK1/eIF4E pathway of mRNA translation. Using lysine and arginine labeled with stable heavy isotopes followed by quantitative mass spectrometry, we determined that GSK-3 inhibition markedly increases (by more than 3-fold) de novo TNF-α protein synthesis. Our findings shed light on a novel mechanism of control of TNF-α expression in neutrophils with GSK-3 regulating mRNA translation and raise the possibility that lithium could be having a hitherto unforeseen effect on inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.14-251900"xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/author | "Laflamme C."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/author | "Pouliot M."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/author | "Servant M.J."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/author | "Rollet-Labelle E."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/author | "Giambelluca M.S."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/author | "Bertheau-Mailhot G."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/pages | "3679-3690"xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/title | "TNF-alpha expression in neutrophils and its regulation by glycogen synthase kinase-3: a potentiating role for lithium."xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/24803542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24803542 |
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