| http://purl.uniprot.org/citations/24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24809472 | http://www.w3.org/2000/01/rdf-schema#comment | "Prep1 and Meis1 ortholog TALE transcription factors have opposing roles in tumorigenesis: Meis1 serves as an oncogene, Prep1 as a tumor suppressor. We now report that, Meis1 overexpression in primary Prep1-deficient (Prep1i/i) embryonic hematopoietic cells increases self-renewal potential of cells in vitro but not in vivo, whereas leukemia is instead obtained when Meis1 is combined with another oncogene, HoxA9. Prep1i/i Meis1-HoxA9-generated leukemic cells are less differentiated and grow more aggressively after the second passage in the mouse. These data indicate that Prep1 represents a barrier to the transforming activity of Meis1 in vitro, but its absence is not sufficient to induce early leukemogenesis. On the other hand, the Prep1i/i background appears to favor the insurgence of mutations that cause a more aggressive Meis1-HoxA9-generated leukemia. Indeed, the Prep1i/i leukemic cells upregulate the Polycomb protein Bmi-1 and expectedly down-regulate the Ink4a/Arf locus products. Finally, an important feature contributed by the Prep1i/i background is the post-transcriptional increase in Meis1 protein level."xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0096711"xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/author | "Blasi F."xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/author | "Iotti G."xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/author | "Dardaei L."xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/author | "Modica L."xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/pages | "e96711"xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/title | "The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24809472 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24809472 |
| http://purl.uniprot.org/citations/24809472 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQB8-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A494B900-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A494B934-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A494B958-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U0-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A494BA52-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A494BAI2-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_A0A494BB27-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_H3BLB6-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_Q3UJ00-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |
| http://purl.uniprot.org/uniprot/#_O70477-mappedCitation-24809472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24809472 |