| http://purl.uniprot.org/citations/24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24811177 | http://www.w3.org/2000/01/rdf-schema#comment | "The glucocorticoid dexamethasone increases cystic fibrosis transmembrane conductance regulator (CFTR) abundance in human airway epithelial cells by a mechanism that requires serum- and glucocorticoid-induced protein kinase 1 (SGK1) activity. The goal of this study was to determine whether SGK1 increases CFTR abundance by phosphorylating Shank2E, a PDZ domain protein that contains two SGK1 phosphorylation consensus sites. We found that SGK1 phosphorylates Shank2E as well as a peptide containing the first SGK1 consensus motif of Shank2E. The dexamethasone-induced increase in CFTR abundance was diminished by overexpression of a dominant-negative Shank2E in which the SGK1 phosphorylation sites had been mutated. siRNA-mediated reduction of Shank2E also reduced the dexamethasone-induced increase in CFTR abundance. Taken together, these data demonstrate that the glucocorticoid-induced increase in CFTR abundance requires phosphorylation of Shank2E at an SGK1 consensus site."xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.555599"xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/author | "Madden D.R."xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/author | "Stanton B.A."xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/author | "Koeppen K."xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/author | "Coutermarsh B.A."xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/pages | "17142-17150"xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/title | "Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein."xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/24811177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24811177 |
| http://purl.uniprot.org/citations/24811177 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24811177 |
| http://purl.uniprot.org/uniprot/#_E9PR89-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_A0A590UJ45-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_B7Z1G1-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_A6NHU9-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_B7ZKU9-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_B7Z325-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_I7D9N1-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_Q24JS4-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_I7C337-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_R4I3I2-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |
| http://purl.uniprot.org/uniprot/#_O00141-mappedCitation-24811177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24811177 |