| http://purl.uniprot.org/citations/24813850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24813850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24813850 | http://www.w3.org/2000/01/rdf-schema#comment | "Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of ripk3, caspase-8, or fadd. However, animals that lack RIPK1, RIPK3, and either caspase-8 or FADD survived weaning and matured normally. RIPK1 functions in vitro to limit caspase-8-dependent, TNFR-induced apoptosis, and animals lacking RIPK1, RIPK3, and TNFR1 survive to adulthood. The role of RIPK3 in promoting lethality in ripk1(-/-) mice suggests that RIPK3 activation is inhibited by RIPK1 postbirth. Whereas TNFR-induced RIPK3-dependent necroptosis requires RIPK1, cells lacking RIPK1 were sensitized to necroptosis triggered by poly I:C or interferons. Disruption of TLR (TRIF) or type I interferon (IFNAR) signaling delayed lethality in ripk1(-/-)tnfr1(-/-) mice. These results clarify the complex roles for RIPK1 in postnatal life and provide insights into the regulation of FADD-caspase-8 and RIPK3-MLKL signaling by RIPK1."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2014.04.018"xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2014.04.018"xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Gong Y.N."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Gong Y.N."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Gurung P."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Gurung P."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Llambi F."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Llambi F."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Brewer T.L."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Brewer T.L."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Cripps J.G."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Cripps J.G."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Dillon C.P."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Dillon C.P."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Janke L.J."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Janke L.J."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Kelliher M.A."xsd:string |
| http://purl.uniprot.org/citations/24813850 | http://purl.uniprot.org/core/author | "Kelliher M.A."xsd:string |