| http://purl.uniprot.org/citations/24819588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24819588 | http://www.w3.org/2000/01/rdf-schema#comment | "Mesenchymal stem cells (MSCs) form part of tumor stroma, and are typically considered to be pro-tumorigenic, promoting continuing tumor growth and metastasis. Here, we describe a mechanism by which MSCs may be anti-tumorigenic, through inhibition of breast cancer cell migration and invasion, an important part of metastasis. MDA-MB-231 and T47D cells were co-cultured in a Transwell insert above MSCs or MSC conditioned media and their migration or invasion through Matrigel measured. The conditioned media was found to inhibit breast cancer cell movement. TIMP-1 and TIMP-2, inhibitors of matrix metalloproteinases (MMPs), were identified as candidates for this inhibition and enhanced secretion of MMPs was not sufficient to counter the anti-migratory effects of TIMP expression. Inhibition of TIMP activity showed that TIMP-1 and TIMP-2 together were largely responsible for the reduction of migration and invasion by MSCs. Therefore, MSCs may play anti-tumorigenic, anti-metastatic roles in tumor development, with the overall outcome dependent upon the balance of pro-and anti-tumorigenic molecules secreted."xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.org/dc/terms/identifier | "doi:10.1002/mc.22178"xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/author | "Imhoff F.M."xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/author | "Baird S.K."xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/author | "Clarke M.R."xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/name | "Mol Carcinog"xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/pages | "1214-1219"xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/title | "Mesenchymal stem cells inhibit breast cancer cell migration and invasion through secretion of tissue inhibitor of metalloproteinase-1 and -2."xsd:string |
| http://purl.uniprot.org/citations/24819588 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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