| http://purl.uniprot.org/citations/24820414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24820414 | http://www.w3.org/2000/01/rdf-schema#comment | "14-3-3τ is frequently overexpressed in breast cancer; however, whether it contributes to breast cancer progression remains undetermined. Here, we identify a critical role for 14-3-3τ in promoting breast cancer metastasis, in part through binding to and inhibition of RhoGDIα, a negative regulator of Rho GTPases and a metastasis suppressor. 14-3-3τ binds Ser174-phosphorylated RhoGDIα and blocks its association with Rho GTPases, thereby promoting epidermal growth factor (EGF)-induced RhoA, Rac1, and Cdc42 activation. When 14-3-3τ is overexpressed in MCF7 breast cancer cells that express 14-3-3τ at low levels, it increases motility, reduces adhesion, and promotes metastasis in mammary fat pad xenografts. On the other hand, depletion of 14-3-3τ in MCF7 cells and in an invasive cell line, MDA-MB231, inhibits Rho GTPase activation and blocks breast cancer migration and invasion. Moreover, 14-3-3τ overexpression in human breast tumors is associated with the activation of ROCK (a Rho GTPase effector), high metastatic rate, and shorter survival, underscoring a clinically significant role for 14-3-3τ in breast cancer progression. Our work indicates that 14-3-3τ is a novel therapeutic target to prevent breast cancer metastasis."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00076-14"xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/author | "Lin W.C."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/author | "Ke S."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/author | "Lin F.T."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/author | "Lin V.Y."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/author | "Lin G.E."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/pages | "2635-2649"xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/title | "14-3-3tau promotes breast cancer invasion and metastasis by inhibiting RhoGDIalpha."xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/24820414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24820414 |
| http://purl.uniprot.org/citations/24820414 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24820414 |
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