| http://purl.uniprot.org/citations/24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24821782 | http://www.w3.org/2000/01/rdf-schema#comment | "The recognition of cytoplasmic nucleic acid is critical for innate immune responses against microbial infection and is responsible for autoimmunity induced by dead cells. Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family. Knocking down DHX29 by siRNA attenuated the ability of cells to mount type I IFN and IL-6 in response to cytosolic nucleic acids and various viruses by blocking the activation of interferon regulatory factor 3 and NF-κB-p65. The cytosolic nucleic acid sensing by DHX29 in human epithelial cells and fibroblasts is independent of stimulator of interferon genes but is dependent on retinoic acid-inducible gene 1 (RIG-I) and mitochondrial antiviral signaling protein (MAVS). DHX29 binds directly to nucleic acids and interacts with RIG-I and MAVS through its helicase 1 domain, activating the RIG-I-MAVS-dependent cytosolic nucleic acid response. These results suggest that DHX29 is a cytosolic nucleic acid cosensor that triggers RIG-I/MAVS-dependent signaling pathways. This study will have important implications in drug and vaccine design for control of viral infections and viral-induced pathology in the airway."xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1400139111"xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/author | "Liu Y.J."xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/author | "Sugimoto N."xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/author | "Kim T."xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/author | "Hanabuchi S."xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/author | "Mitoma H."xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/pages | "7747-7752"xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/title | "Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system."xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24821782 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24821782 |
| http://purl.uniprot.org/citations/24821782 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24821782 |
| http://purl.uniprot.org/uniprot/#_B3KN51-mappedCitation-24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24821782 |
| http://purl.uniprot.org/uniprot/#_B4DWT9-mappedCitation-24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24821782 |
| http://purl.uniprot.org/uniprot/#_B3KWW1-mappedCitation-24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24821782 |
| http://purl.uniprot.org/uniprot/#_Q3B797-mappedCitation-24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24821782 |
| http://purl.uniprot.org/uniprot/#_L8E813-mappedCitation-24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24821782 |
| http://purl.uniprot.org/uniprot/#_O95786-mappedCitation-24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24821782 |
| http://purl.uniprot.org/uniprot/#_Q7Z478-mappedCitation-24821782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24821782 |
| http://purl.uniprot.org/uniprot/B4DWT9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24821782 |
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| http://purl.uniprot.org/uniprot/O95786 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24821782 |