| http://purl.uniprot.org/citations/24822215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24822215 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-33 appears to play important roles in the induction of allergic airway inflammation. However, whether IL-33 is involved in airway remodeling remains unclear. Because fibrocytes contribute to tissue remodeling in the setting of chronic inflammation, we examined the effects of IL-33 on fibrocyte functions. Fibrocytes were generated in vitro from peripheral blood mononuclear cells by culturing in the presence of platelet derived growth factors and the cells were stimulated with IL-33. IL-33 enhanced cell proliferation, α-SMA expression, and pro-MMP-9 activity by the fibrocytes without increasing endogenous transforming growth factor-β1 production. Fibrocytes constitutively expressed IL-13 and IL-5, and their production was augmented by stimulation with IL-33. Dexamethasone inhibited the functions of fibrocytes, but IL-33 made fibrocytes slightly refractory to the inhibitory effect of dexamethasone in terms of IL-13 production. Montelukast suppressed IL-13 production by nonstimulated fibrocytes but not those stimulated by IL-33. These findings suggest that IL-33 is involved in the airway remodeling process through its modulation of fibrocyte function independent of antigen stimulation. IL-33 might partially reduce the therapeutic effects of glucocorticoid and cysteinyl leukotriene receptor antagonist on fibrocyte-mediated Th2 responses."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.org/dc/terms/identifier | "doi:10.1155/2014/738625"xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/author | "Hayashi H."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/author | "Okazaki S."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/author | "Ohshima Y."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/author | "Murai H."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/author | "Yasutomi M."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/author | "Kawakita A."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/pages | "738625"xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/title | "IL-33 enhanced the proliferation and constitutive production of IL-13 and IL-5 by fibrocytes."xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://purl.uniprot.org/core/volume | "2014"xsd:string |
| http://purl.uniprot.org/citations/24822215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24822215 |
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