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| http://purl.uniprot.org/citations/24828139 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes is increasingly becoming a major cause of large-scale morbidity and mortality. Diabetes-induced oxidative stress alters numerous intracellular signaling pathways. Although testicular dysfunction is a major concern in diabetic men, the mechanistic alterations in the testes that lead to hypogonadism are not yet clear. Oxidative mitochondrial DNA damage, as indicated by 7,8-dihydro-8-oxo-2'-deoxyguanosine, and phosphorylation of p53 at ser315 residue (p-p53ser315) increased in a stage- and cell-specific manner in the testes of rats that were diabetic for 1 month (DM1). Prolongation of diabetes for 3 months (DM3) led to an increase in nuclear oxidative DNA damage in conjunction with a decrease in the expression of p-p53ser315. The nuclei of pachytene and preleptotene spermatocytes, steps 1, 11, and 12 spermatids, secondary spermatocytes and the Sertoli cells, and the meiotic figures showed an increase in the expression of p-p53ser315. An increase in the expression of a downstream target of p53 and protein 21(cyclin-dependent kinase interacting protein 1/wild-type p53-activated factor 1) (p21(CIP1/Waf1)) in both diabetic groups did not show any time-dependent effects but occurred concurrent with an upregulation of p-p53ser315 in DM1 and a downregulation of the protein in DM3. In diabetic groups, the expression of p21(CIP1/Waf1) was mainly cytoplasmic but also perinuclear in pachytene spermatocytes and round spermatids. The cytoplasmic localization of p21(CIP1/Waf1) may be suggestive of an antiapoptotic role for the protein. The perinuclear localization is probably related to the cell cycle arrest meant for DNA damage repair. Diabetes upregulates p21(CIP1/Waf1) signaling in testicular germ cells in association with alteration in p-p53ser315 expression, probably to counteract DNA damage-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/24828139 | http://purl.org/dc/terms/identifier | "doi:10.1177/1933719114533729"xsd:string |
| http://purl.uniprot.org/citations/24828139 | http://purl.uniprot.org/core/author | "Al-Bader M.M."xsd:string |
| http://purl.uniprot.org/citations/24828139 | http://purl.uniprot.org/core/author | "Kilarkaje N."xsd:string |
| http://purl.uniprot.org/citations/24828139 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24828139 | http://purl.uniprot.org/core/name | "Reprod Sci"xsd:string |
| http://purl.uniprot.org/citations/24828139 | http://purl.uniprot.org/core/pages | "102-112"xsd:string |
| http://purl.uniprot.org/citations/24828139 | http://purl.uniprot.org/core/title | "Diabetes-induced oxidative DNA damage alters p53-p21CIP1/Waf1 signaling in the rat testis."xsd:string |
| http://purl.uniprot.org/citations/24828139 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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