| http://purl.uniprot.org/citations/24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24829406 | http://www.w3.org/2000/01/rdf-schema#comment | "As one of the most common posttranslational modifications (PTMs) of eukaryotic proteins, N(α)-terminal acetylation (Nt-acetylation) generates a class of N(α)-acetylpeptides that are known to be presented by MHC class I at the cell surface. Although such PTM plays a pivotal role in adjusting proteolysis, the molecular basis for the presentation and T cell recognition of N(α)-acetylpeptides remains largely unknown. In this study, we determined a high-resolution crystallographic structure of HLA (HLA)-B*3901 complexed with an N(α)-acetylpeptide derived from natural cellular processing, also in comparison with the unmodified-peptide complex. Unlike the α-amino-free P1 residues of unmodified peptide, of which the α-amino group inserts into pocket A of the Ag-binding groove, the N(α)-linked acetyl of the acetylated P1-Ser protrudes out of the groove for T cell recognition. Moreover, the Nt-acetylation not only alters the conformation of the peptide but also switches the residues in the α1-helix of HLA-B*3901, which may impact the T cell engagement. The thermostability measurements of complexes between N(α)-acetylpeptides and a series of MHC class I molecules derived from different species reveal reduced stability. Our findings provide the insight into the mode of N(α)-acetylpeptide-specific presentation by classical MHC class I molecules and shed light on the potential of acetylepitope-based immune intervene and vaccine development."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1400199"xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/author | "Gao G.F."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/author | "Qi J."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/author | "Sun M."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/author | "Tefsen B."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/pages | "5509-5519"xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/title | "Nalpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted nalpha-acetylpeptide presentation."xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24829406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24829406 |
| http://purl.uniprot.org/citations/24829406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |
| http://purl.uniprot.org/uniprot/#_A0A068B2J5-mappedCitation-24829406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24829406 |