| http://purl.uniprot.org/citations/24833351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24833351 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammation is a key process in various diseases, characterized by leukocyte recruitment to the inflammatory site. This study investigates the role of a disintegrin and a metalloproteinase (ADAM) 10 and ADAM17 for leukocyte migration in vitro and in a murine model of acute pulmonary inflammation. Inhibition experiments or RNA knockdown indicated that monocytic THP-1 cells and primary human neutrophils require ADAM10 but not ADAM17 for efficient chemokine-induced cell migration. Signaling and adhesion events that are linked to cell migration such as p38 and ρ GTPase-family activation, F-actin polymerization, adhesion to fibronectin, and up-regulation of α5 integrin were also dependent on ADAM10 but not ADAM17. This was confirmed with leukocytes isolated from mice lacking either ADAM10 or ADAM17 in all hematopoietic cells (vav 1 guanine nucleotide exchange factor [Vav]-Adam10(-/-) or Vav-Adam17(-/-) mice). In lipopolysaccharide-induced acute pulmonary inflammation, alveolar recruitment of neutrophils and monocytes was transiently increased in Vav-Adam17(-/-) but steadily reduced in Vav-Adam10(-/-) mice. This deficit in alveolar leukocyte recruitment was also observed in LysM-Adam10(-/-) mice lacking ADAM10 in myeloid cells and correlated with protection against edema formation. Thus, with regard to leukocyte migration, leukocyte-expressed ADAM10 but not ADAM17 displays proinflammatory activities and may therefore serve as a target to limit inflammatory cell recruitment."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-09-511543"xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Saftig P."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Uhlig S."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Schwarz N."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Ludwig A."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Hess F.M."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Groth E."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Pruessmeyer J."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Dreymueller D."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "van der Vorst E."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Donners M."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Alert H."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Kollert J."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Nyamoya S."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/author | "Pasqualon T."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/pages | "4077-4088"xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/title | "Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space."xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/24833351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24833351 |
| http://purl.uniprot.org/citations/24833351 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24833351 |