| http://purl.uniprot.org/citations/24835196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24835196 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the beneficial responses induced in the central nervous system by early-initiated exercise have been broadly investigated, the effects of a chronic and moderate lately-initiated exercise on biochemical hallmarks of very early brain senescence have not been extensively studied. We previously reported that a midlife-initiated regimen of moderate running was able not only to prevent the age-related decay of antioxidative and detoxification functions in mouse brain cortex, but also to preserve neurotrophic support and molecular integrity. On this basis, this work investigated whether and how a 2-mo or 4-mo midlife-initiated running protocol could affect the activity of those systems involved in maintaining neuronal function and in preventing the onset of neurodegeneration within the brain cortex of middle-aged CD-1 mice. In particular, we analyzed the production of the peptide amyloid-β and the expression of synapsin Ia, which is known to play a key role in neurotransmission and synaptic plasticity. In addition, we studied the expression of sirtuin 3, as a protein marker of neuroprotection against age-dependent mitochondrial dysfunction, as well as the pro-death pathway induced by proBDNF through the interaction with p75NTR and the co-receptor sortilin. The midlife-initiated 4-mo running program triggered multiple responses within the mouse brain cortex, through the activation of anti-amyloidogenic, pro-survival, synaptogenic and neuroprotective pathways. However, most of the beneficial actions of the exercise regimen appeared only after 4months, since 2-mo-exercised mice showed marked impairments of the endpoints we considered. This could imply that a midlife-initiated regimen of moderate treadmill running may require an adequate time lag to activate beneficial compensative mechanisms within the mouse brain cortex."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exger.2014.05.006"xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/author | "Sebastiani P."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/author | "D'Alessandro A."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/author | "Amicarelli F."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/author | "Cacchio M."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/author | "Di Loreto S."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/author | "Falone S."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/author | "Santini S. Jr."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/name | "Exp Gerontol"xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/pages | "57-65"xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/title | "Regular and moderate exercise initiated in middle age prevents age-related amyloidogenesis and preserves synaptic and neuroprotective signaling in mouse brain cortex."xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/24835196 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24835196 |
| http://purl.uniprot.org/citations/24835196 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24835196 |
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| http://purl.uniprot.org/uniprot/W8QPF2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24835196 |
| http://purl.uniprot.org/uniprot/O88935 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24835196 |