| http://purl.uniprot.org/citations/24836425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24836425 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factors TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4(+)CD8(+) double-positive (DP) stage are unknown. By specific ablation of these factors in DP thymocytes, we demonstrated that deficiency in TCF-1 and LEF-1 diminished the output of CD4(+) T cells and redirected CD4(+) T cells to a CD8(+) T cell fate. The role of TCF-1 and LEF-1 in the CD4-versus-CD8 lineage 'choice' was mediated in part by direct positive regulation of the transcription factor Th-POK. Furthermore, loss of TCF-1 and LEF-1 unexpectedly caused derepression of CD4 expression in T cells committed to the CD8(+) lineage without affecting the expression of Runx transcription factors. Instead, TCF-1 physically interacted with Runx3 to cooperatively silence Cd4. Thus, TCF-1 and LEF-1 adopted distinct genetic 'wiring' to promote the CD4(+) T cell fate and establish CD8(+) T cell identity."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2897"xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "He B."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Tan K."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Yu S."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Xue H.H."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Kawamoto H."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/author | "Steinke F.C."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/pages | "646-656"xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/title | "TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/24836425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24836425 |
| http://purl.uniprot.org/citations/24836425 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24836425 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-24836425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24836425 |
| http://purl.uniprot.org/uniprot/#_D3YXC8-mappedCitation-24836425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24836425 |
| http://purl.uniprot.org/uniprot/#_A0A5K1VVQ7-mappedCitation-24836425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24836425 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPS9-mappedCitation-24836425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24836425 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-24836425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24836425 |